Antioxidant enhancement of therapy for hyperproliferative conditions
AssigneeAtheroGenics, Inc.
InventorsRebecca Chinery, R. Daniel Beauchamp, Robert J. Coffey, Russell M. Medford, Brian E. Wadzinski
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Abstract
A method to enhance the cytotoxic activity of an antineoplastic drug comprising administering an effective amount of the antineoplastic drug to a host exhibiting abnormal cell proliferation in combination with an effective cytotoxicity-increasing amount of an antioxidant. The invention also includes a method to decrease the toxicity to an antineoplastic agent or increase the therapeutic index of an antineoplastic agent administered for the treatment of a solid growth of abnormally proliferating cells, comprising administering an antioxidant prior to, with, or following the antineoplastic treatment.
Claims14
A method to enhance the cytotoxicity of an antineoplastic drug for the treatment of a disorder of abnormal cell proliferation, the method comprising administering an effective amount of the antineoplastic drug to a host in need of such treatment in combination with an effective cytotoxicity-increasing amount of an antioxidant, wherein the antioxidant is a mono-ester or di-ester of probucol.
Dependencies are inferred from the claim text.