Cells expressing a CD4-IgG2 chimeric heterotetramer
AssigneeProgenics Pharmaceuticals, Inc.
InventorsGary A. Beaudry, Paul J. Maddon
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Abstract
This invention provides an expression vector encoding a CD4-gamma2 chimeric heavy chain homodimer. This invention also provides an expression vector encoding the heavy chains of a CD4-IgG2 chimeric heterotetramer. Finally, this invention provides an expression vector encoding the light chains of a CD4-IgG2 chimeric heterotetramer.
Claims9
A transformed host cell comprising at least two vectors, one vector comprising a DNA sequence encoding heavy chains of a CD4-IgG2 chimeric heterotetramer, and one vector comprising a DNA sequence encoding light chains of the CD4-IgG2 chimeric heterotetramer, wherein the CD4-IgG2 chimeric heterotetramer comprises two heavy chains having the amino acid sequence set forth in SEQ ID NO:
- 4, and two light chains having the amino acid sequence set forth in SEQ ID NO:
- 6, and wherein the CD4-IgG2 chimeric heterotetramer produced in the cell is capable of neutralizing an HIV-1-infected individual's HIV-1 virus.
Dependencies are inferred from the claim text.