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US 7,070,987 B2Granted
Guided mode resonant filter biosensor using a linear grating surface structure
AssigneeSRU Biosystems, Inc.
InventorsBrian T. Cunningham, Jane Pepper, Bo Lin, Peter Li, Jean Qiu, Homer Pien
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Abstract
Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters.
Claims13
A biosensor comprising:
- (a) a one-dimensional grating layer comprised of a material having a high refractive index;
- (b) a low refractive index material layer that supports the one-dimensional grating layer;
- and
- (c) one or more specific binding substances immobilized on the surface of the one-dimensional grating layer opposite of the low refractive index material layer;
- wherein the one or more specific binding substances are bound to their binding partners and wherein one or more specific binding substances and their binding partners are detection label-free,
- wherein, when the biosensor is illuminated a resonant grating effect is produced on a reflected radiation spectrum, and wherein cross-section of the one-dimensional grating is less than the wavelength of the resonant grating effect.
3 more elements
Dependencies are inferred from the claim text.