Glycosyl sulfotransferases GST-4α, GST-4β, and GST-6
AssigneesSyntex (U.S.A.) Inc., The Regents of the University of California
InventorsSteven Rosen, Jin Kyu Lee, Stefan Hemmerich
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Abstract
Novel glycosylsulfotransferases (GST-4α, GST-4β, and GST-6) and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including various diagnostic and therapeutic agent screening applications. Also provided are methods of inhibiting selectin mediated binding events and methods of treating disease conditions associated therewith, particularly by administering an inhibitor of at least one of GST-4α, GST-4β, and GST-6.
Claims5
A glycosyl sulfotransferase (GST) polypeptide present in other than its natural environment, wherein said GST polypeptide comprises an amino acid sequence having at least about 75% amino acid sequence identity to the amino acid sequence set forth in SEQ ID NO:8 wherein said GST polypeptide exhibits N-acetyl glucosamine-6-O-sulfotransferase activity.
Dependencies are inferred from the claim text.