US 7,070,964 B2 · Epothilone compounds and methods for making the same

Abstract

The present invention provides bioconversion methods for making epothilone analogs. These analogs differ from the starting material by the addition of one or more hydroxyl groups or by the addition of an epoxide. These compounds, in turn, can be further modified by chemical synthesis.

Claims1

Dependent claims

A bioconversion method comprising the steps of contacting Amycolata autotrophica ATCC 35203 with a compound of the structure

to yield a compound of the structure
wherein R is hydrogen or methyl.

Dependencies are inferred from the claim text.

Facts

Application

10/295,342Filed 14 Nov 2002 · us provisional application

Priority

15 Nov 2001

Published

US 2003/0219877 A127 Nov 2003

Granted

4 Jul 2006

Term ends

Not estimatedThe source records don’t support an estimate.

Classification7 codes

C07D 417/06
Containing two hetero rings: linked by a carbon chain containing only aliphatic carbon atoms
C07D 493/04
In which the condensed system contains two hetero rings: ortho-condensed systems
C07D 493/08
In which the condensed system contains two hetero rings: bridged systems
C12P 17/167
Containing two or more hetero rings: heterorings having sulfur atoms as ring heteroatoms, e.g. vitamin B1, thiamine nucleus and open chain analogs

Epothilone compounds and methods for making the same

Life of this patent

Abstract

Claims1

Epothilone compounds and methods for making the same

Life of this patent

Abstract

Claims1