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US 7,070,940 B2Granted
Method for determining the ability of a compound to modify the interaction between parkin and the p38 protein
AssigneeAventis Pharma S.A.
InventorsOlga Corti, Cornelia Hampe, Alexis Brice, Laurent Pradier, Thomas Rooney, Alain Fournier
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Abstract
The present invention relates to a method for determining the ability of a compound to modify the interaction between parkin and the p38 protein, and in particular to a method for screening for or detecting compounds intended for the prevention and/or treatment of neurodegenerative pathological conditions. The present inventions also relates to compounds identified in the above screening method.
Claims6
A method for screening a candidate compound for effectiveness in modifying the interaction between a p38 protein and a parkin protein comprising the steps of:
- a) exposing a sample comprising said p38 protein and parkin protein to said candidate compound;
- and
- b) measuring the interaction between said p38 protein to said parkin protein and comparing it to a control sample comprising said p38 protein and parkan protein without said candidate compound.
Dependencies are inferred from the claim text.