Amorphous polymeric polyaxial initiators and compliant crystalline copolymers therefrom
AssigneePoly-Med, Inc.
InventorsShalaby W. Shalaby, Torbjorn Mathisen
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Abstract
An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent. The present invention also relates to a suture, stents, stent mantles and sealing devices made from the polyaxial copolymer.
Claims7
A composite tubular cover or mantle for a stent comprising a polymeric matrix reinforced with monofilament cross-spirals, wherein at least one of the matrix and the reinforcement comprise an absorbable, crystalline, monocentric, polyaxial copolymer comprising:
- a central atom selected from the group consisting of carbon and nitrogen;
- and
- at least three axes originating and extending outwardly from the central atom, each axis comprising:
- an amorphous, flexible component adjacent to and originating from the central atom, the amorphous component comprising repeat units derived from at least one cyclic monomer selected from the group consisting essentially of carbonates and lactones;
- and
- a rigid, crystallizable component extending outwardly from the amorphous, flexible component, the crystallizable component comprising repeat units derived from at least one lactone;
- wherein the copolymer comprises a melting temperature greater than 120° C., a heat of fusion greater than 10 J/g, and an endothermic transition at 40–100° C., wherein the endothermic transition can be controlled by subsequent heat treatment of the copolymer.
Dependencies are inferred from the claim text.