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US 7,070,808 B2Granted
Adhesive mixture for transdermal delivery of highly plasticizing drugs
AssigneeMylan Technologies, Inc.
InventorsSharad K. Govil, Ludwig J. Weimann
Life of this patent
Estimating the term…
Abstract
Transdermal drug delivery patches and methods of their production are described. The patches can be made such that the accommodate highly plasticizing drugs such as selegiline and/or the use of protonated forms of various drugs.
Claims17
A therapeutic adhesive formulation comprising:
- between about 65% and about 97%, by weight, of an acrylic polymeric adhesive which includes between about 40% and about 90% of a C4–C12 alkyl acrylate, between about 10% and about 40% by weight of a C1–C4 alkyl acrylare hardening monomer;
- between about 1% and about 20% by weight of a monomer which provides functional groups for crosslinking;
- and a crosslinking agent;
- and
- between about 3% and about 35% by weight, based on the weight of said mixture, of a highly plasticizing drug.
2 more elements
A drug containing and releasing adhesive mixture comprising:
- between about 65% and about 97%, by weight of an acrylic polymeric adhesive which includes between about 60% and about 80% of a C4–C12 alkyl acrylate selected from the group consisting of 2-ethylhexyl acrylate, butyl acrylate, n-decyl, n-nonyl, 2 ethyoctyl, isooctyl and dodecyl-acrylate;
- between about 15% and about 30% by weight of a C1–C4 alkyl acrylate hardening monomer selected front the group consisting of methyl acrylate, methyl methacrylate, ethylacrylate, ethyl methacrylate, hydroxyethyl acrylate and hydroxy propyl methacrylate;
- between about 1% and about 20% by weight of a functionalizing monomer which facilitates crosslinking selected from the group consisting of acrylic acid, hydroxy ethylacrylate, methacrylic acid and acrylamide;
- and a crosslinking agent provided in an amount of between about 0.005% and about 2.0%;
- and
- between about 3% and about 35% by weight, based on the weight of said mixture, of a highly plasticizing drug selected from the group consisting of selegiline, fluoxetine, des-methyl selegiline, tetracaine and chlorpheniramine.
3 more elements
Dependencies are inferred from the claim text.