Sugar-modified liposome and products comprising the liposome
AssigneeNational Institute of Advanced Industrial Science and Technology
InventorsNoboru Yamazaki, Shuji Kojima
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Abstract
The present invention provides a sugar-modified liposome having a sugar chain bonded to its membrane surface, preferably through a linker protein, and having excellent absorption qualities, particularly in the intestine. The molecular structure and quantity of the sugar chain is selectively varied to allow the liposome to be delivered in a targeted manner to selected cells and tissues. The liposome is applicable to medicinal drugs, cosmetics and other various products in the medical/pharmaceutical fields, and it is especially useful in a therapeutic drug delivery system that recognizes target cells and tissues, such as cancer cells, and in the delivery of drugs or genes locally to a selected region, or in a diagnostic cell/tissue sensing probe.
Claims15
A liposome comprising:
- (a) at least one sugar chain bonded to the membrane surface of the liposome;
- and
- (b) a hydrophilizing moiety bonded to the membrane surface of the liposome in addition to the sugar chain;
- wherein the hydrophilizing moiety is tris (hydroxymethyl) aminomethane.
A liposome comprising:
- (a) at least one sugar chain bonded to the membrane surface of the liposome;
- (b) a hydrophilizing moiety bonded to the membrane surface of the liposome in addition to the sugar chain;
- (c) a linker protein bonded to the membrane surface of the liposome, wherein the sugar chain is bonded to the membrane surface of the liposome through the linker protein;
- and
- (d) an additional hydrophilizing moiety bonded to the linker protein in addition to the sugar chain.
Dependencies are inferred from the claim text.