Nucleotide and deduced amino acid sequences of the envelope 1 and core genes of isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsJens Bukh, Roger H. Miller, Robert H. Purcell
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Abstract
The nucleotide and deduced amino acid sequences of cDNAs encoding the envelope 1 genes and core genes of isolates of hepatitis C virus (HCV) are disclosed. The invention relates to the oligonucleotides, peptides and recombinant envelope 1 and core proteins derived from these sequences and their use in diagnostic methods and vaccines.
Claims23
A purified and isolated protein encoded by the gene sequence of SEQ ID NO:
- 154.
A purified and isolated protein having the amino acid sequence of SEQ ID NO:
- 206.
A hepatitis C virus kit comprising:
- at least one protein comprising an the amino acid sequence of SEQ ID NO:
- 206.
An isolated genotype-specific peptide comprising an amino acid sequence of at least 8 contiguous amino acids from SEQ ID NO:
- 206, said peptide having at least one of the following residues:
- Q72, H75, H106, A149, and I158;
- and wherein genotype-specific is defined as belonging to the single genotype 6a (type 6) of HCV.
An isolated universally conserved peptide consisting of an amino acid sequence of at least 8 amino acids deduced from universally conserved amino acid domains found in SEQ ID NO:
- 206, wherein universally conserved is defined as belonging to all genotypes of HCV with reference to FIG. 7K.
Dependencies are inferred from the claim text.