Method of inducing the production of antibodies to HIV
AssigneeDuke University
InventorsBarton F. Haynes, Dhavalkumar D. Patel, Munir Alam, Hua-Xin Liao
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Abstract
The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates. The invention also relates to a method of inducing anti-HIV antibodies using same.
Claims18
A method of inducing the production of antibodies to HIV in a mammal comprising administering to said mammal an amount of an immunogen comprising an HIV envelope protein bound to a ligand, which ligand upregulates at least one of the CD4 binding site and the CCR5 binding site on said protein, wherein said immunogen is administered in an amount sufficient to effect said induction.
Dependencies are inferred from the claim text.