Delivery of diphenhydramine through an inhalation route

A method of producing diphenhydramine in an aerosol form comprising:

• a. heating a thin layer containing diphenhydramine, on a solid support, to produce a vapor of diphenhydramine, and
• b. providing an air flow through the vapor to form a condensation aerosol characterized by less than 10% drug degradation products by weight, and an MMAD of less than 5 microns.

A kit for delivering a diphenhydramine condensation aerosol comprising:

• a. a thin layer containing diphenhydramine, on a solid support, and
• b. a device for providing the condensation aerosol, wherein the condensation aerosol is formed by heating the thin layer to produce a vapor of diphenhydramine, and condensing the vapor to form a condensation aerosol characterized by less than 10% diphenhydramine degradation products by weight, and an MMAD of less than 5 microns.