Skin test for schizophrenia
AssigneeYeda Research and Development Co. Ltd.
InventorsMeir Shinitzky, Michael Deckmann
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Abstract
A diagnostic method for assaying schizophrenia in a subject is provided wherein a preparation comprising platelet derived proteins or fractions thereof having a pI above about 6.5 is injected into a subject and the occurrence of delayed type hypersensitivity (DTH) reaction at the site of the injection is determined. A positive DTH reaction indicates that the tested subject has a high likelihood of being schizophrenic. The protein preparation used in the diagnostic method is also provided as well as a method for its preparation and a kit for use in the diagnosis of schizophrenia using the above method.
Claims4
A method for the preparation of a reagent for use in diagnosis of schizophrenia in an individual by detecting a DTH reaction in said individual following injection of said reagent to the individual, comprising
- a) obtaining blood samples from a number of individuals, preparing a pool from said samples and collecting platelets therefrom;
- b) preparing a protein fraction from said platelet preparation comprising proteins or fractions thereof, wherein the pI of said proteins or fractions thereof is about 6.5 to about 9.5;
- c) injecting the platelet preparation of step b) into a subject;
- and
- d) detecting the occurrence of a DTH reaction at the site of injection, wherein a positive result is a reaction above that observed in a non-schizophrenic subject under similar conditions, and it indicates that the subject has a high likelihood of being schizophrenic.
A diagnostic method for determining schizophrenia in a subject comprising
- a) obtaining a preparation comprising platelet derived proteins or fractions thereof, wherein the pI of said proteins or fractions thereof is about 6.5 to about 9.5;
- b) injecting said preparation into a subject;
- and
- c) examining the subject for the occurrence of delayed type hypersensitivity reaction at the site of the injection, a positive result being a reaction above that which is observed in non-schizophrenic subjects, indicating that the subject has a high likelihood of being schizophrenic.
A diagnostic method for determining schizophrenia in a subject comprising:
- (a) obtaining a blood sample from a number of schizophrenic or non schizophrenic individuals other than the tested subject and collecting platelets therefrom;
- (b) preparing a protein fraction from said platelet separation comprising proteins or fractions thereof, wherein the pI of said proteins or fractions thereof is about 6.5 to about 9.5;
- (c) injecting said protein preparation into a subject;
- and
- (d) examining the subject for the occurrence of a delayed type hypersensitivity reaction at the site of the injection, a positive result being a reaction above that which is observed in non-schizophrenic subjects, indicating that the subject has a high likelihood of being schizophrenic.
A diagnostic method for determining schizophrenia in a subject comprising:
- a) obtaining a blood sample from an individual and collecting platelets therefrom;
- b) collecting proteins or fractions thereof from said platelet sample, wherein the pI of said proteins or fractions is about 6.5 to about 9.5;
- c) injecting said collected proteins or fractions thereof to the tested individual;
- and
- d) examining the subject for the occurrence of delayed type hypersensitivity reaction at the site of the injection, a positive result being a reaction above that which is observed in non-schizophrenic subjects, indicating that the subject has a high likelihood of being schizophrenic.
Dependencies are inferred from the claim text.