Microchip drug delivery devices
AssigneeMassachusetts Institute of Technology
InventorsJohn T. Santini, Jr., Michael J. Cima, Robert S. Langer
Life of this patent
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Abstract
Devices are provided for the controlled release of drug or other molecules. The devices include (1) a substrate, which optionally includes two or more substrate portions bonded together, (2) at least two reservoirs in the substrate, (3) a release system disposed in the reservoirs that includes the molecules for release and optionally a matrix material, and (4) active or passive means for controlling release of the molecules from the reservoirs. In one embodiment, a reservoir cap is positioned on, or within a portion of, the reservoir and over the molecules, so that the molecules are controllably released from the device by diffusion through or upon disintegration of the reservoir cap.
Claims32
An implantable medical device for the controlled release of drug molecules comprising:
- a substrate;
- at least two discrete reservoirs provided in spaced positions in the substrate;
- and
- a release system disposed in the at least two reservoirs, the release system including drug molecules dispersed in a matrix material,
- wherein the medical device is implantable inside a patient and the rate of release of the drug molecules from the reservoir in vivo is controlled by the matrix material.
An implantable medical device for the controlled release of drug molecules comprising:
- a substrate;
- at least two discrete reservoirs provided in spaced positions in the substrate;
- a release system disposed in the at least two reservoirs, the release system including drug molecules dispersed in a matrix material;
- at least two discrete degradable reservoir caps covering the at least two reservoirs,
- wherein the rate of release of the drug molecules from the reservoir in vivo is controlled by the matrix material.
An implantable medical device for the controlled release of drug molecules comprising:
- a substrate;
- at least two discrete reservoirs provided in spaced positions in the substrate;
- a release system disposed in the at least two reservoirs, the release system including drug molecules dispersed in a degradable matrix material;
- wherein the rate of release of the drug molecules from the reservoir in vivo is controlled by the matrix material.
A microchip device for the controlled release of molecules comprising:
- a substrate;
- an array of two or more spaced apart reservoirs in the substrate,
- a release system disposed in the reservoirs, the release system comprising chemical molecules for release;
- and
- discrete polymeric reservoir caps positioned over or within openings of said at least two reservoirs,
- wherein the release of the molecules from each reservoir is passively controlled by disintegration of the reservoir cap.
Dependencies are inferred from the claim text.