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US 7,070,582 B2Granted
Injection devices that provide reduced outflow of therapeutic agents and methods of delivering therapeutic agents
AssigneeBoston Scientific Scimed, Inc.
InventorsToby Freyman, Wendy Naimark, Tim Mickley, Samuel J. Epstein
Life of this patent
Estimating the term…
Abstract
Injection devices are provided, which reduce potential outflow of therapeutic agents from an injection site. Devices are provided having at least a first lumen containing one or more therapeutic agents and a second lumen containing a second material for injection into tissue. Other devices are provided having an inner lumen with an injection needle to inject a therapeutic agent and an outer lumen that provides a vacuum seal between the injection needle and the needle track. Further provided are methods of delivering a therapeutic agent to tissue.
Claims11
A therapeutic delivery system comprising:
- a first lumen having a proximal end and a distal therapeutic delivery end;
- and
- a second lumen having a proximal end and a distal orifice,
- the first lumen slidable relative to the second lumen,
- the second lumen slidable relative to the first lumen,
- the distal therapeutic delivery end of the first lumen extendible past the distal orifice of the second lumen,
- the distal orifice of the second lumen in fluid communication with an outside surface of the first lumen,
- the distal therapeutic delivery end of the first lumen having a piercing portion
- wherein a tissue sealing gasket is coupled to a surface of the first lumen and wherein the tissue sealing gasket has a tapered cross-section, a smaller portion of the tapered cross section being closer to the piercing portion than a larger portion of the tapered cross section.
6 more elements
A therapeutic delivery system comprising:
- a first lumen having a proximal end and a distal therapeutic delivery end;
- and
- a second lumen having a proximal end and a distal orifice,
- the first lumen slidable relative to the second lumen,
- the second lumen slidable relative to the first lumen,
- the distal therapeutic delivery end of the first lumen extendible past the distal orifice of the second lumen,
- the distal orifice of the second lumen in fluid communication with an outside surface of the first lumen,
- the distal therapeutic delivery end of the first lumen having a piercing portion
- wherein a tissue sealing gasket is coupled to a surface of the first lumen and
- wherein a surface of the gasket is from about 1 mm to about 5 mm from the piercing end of the first lumen and the gasket contains a sloped surface mimicking a sloped surface on the second lumen.
7 more elements
A therapeutic delivery system comprising:
- a first lumen having a proximal end and a distal therapeutic delivery end;
- and
- a second lumen having a proximal end and a distal orifice,
- the first lumen slidable relative to the second lumen,
- the second lumen slidable relative to the first lumen,
- the distal therapeutic delivery end of the first lumen extendible past the distal orifice of the second lumen,
- the distal orifice of the second lumen in fluid communication with an outside surface of the first lumen,
- the distal therapeutic delivery end of the first lumen having a piercing portion
- wherein the second lumen is coupled to a vacuum source, the vacuum source creating a vacuum large enough to draw tissue, being delivered therapeutic by the system, towards and against an external surface of the first therapeutic delivery lumen and
- wherein the vacuum source includes a plunger and a locking ratchet in communication with the plunger.
7 more elements
A therapeutic delivery system comprising:
- a first lumen having a proximal end and a distal therapeutic delivery end;
- and
- a second lumen having a proximal end and a distal orifice,
- the first lumen slidable relative to the second lumen,
- the second lumen slidable relative to the first lumen,
- the distal therapeutic delivery end of the first lumen extendible past the distal orifice of the second lumen,
- the distal orifice of the second lumen in fluid communication with an outside surface of the first lumen,
- the distal therapeutic delivery end of the first lumen having a piercing portion
- wherein a tissue sealing gasket is coupled to a surface of the first lumen and wherein the gasket is coated.
6 more elements
A therapeutic delivery system comprising:
- a first lumen having a proximal end, a distal therapeutic delivery end, and a tissue sealing gasket coupled to a surface of the first lumen;
- and
- a second lumen having a proximal end and a distal orifice,
- the first lumen slidable relative to the second lumen,
- the second lumen slidable relative to the first lumen,
- the distal therapeutic delivery end of the first lumen extendible past the distal orifice of the second lumen,
- the distal orifice of the second lumen in fluid communication with an outside surface of the first lumen when the delivery end of the first lumen is extending past the distal orifice of the second lumen,
- the distal therapeutic delivery end of the first lumen having a piercing portion,
- wherein a surface of the tissue sealing gasket is roughened.
6 more elements
A therapeutic delivery system comprising:
- a first lumen having a proximal end and a distal therapeutic delivery end;
- and
- a second lumen having a proximal end and a distal orifice,
- the first lumen slidable relative to the second lumen,
- the second lumen slidable relative to the first lumen,
- the distal therapeutic delivery end of the first lumen extendible past the distal orifice of the second lumen, an outside surface of the first lumen extendible past the distal orifice of the second lumen having a gasket coupled to the outside surface,
- the distal orifice of the second lumen in fluid communication with an outside surface of the first lumen,
- the distal therapeutic delivery end of the first lumen having a piercing end.
5 more elements
Dependencies are inferred from the claim text.