Method for determining haemodynamic indices by use of tomographic data
OwnerLeif Østergaardinventor
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Abstract
Haemodynamic indices of an organ or a part of tissue are determined from a time series of tomographic data obtained by means of Magnetic Resonance Imaging. Maps of indices are produced, being significant of the dynamics of the capillary tissue flow acquired during rapid bolus injection of a tracer that stays mainly intravascular. The method may be used for evaluating the efficacy of a drug on an organ, or for obtaining information of the likelihood of recovery of an organ or part of tissue upon or during a period of insufficient vascular supply or during the progression of a chronic disease. The method may be used for discriminating between relevant therapy of an organ.
Claims31
Method for determining haemodynamic indices of an organ or of a part of tissue of a mammal including
- a) determining a time series of tomographic data pertaining to the organ or part of tissue during and after a bolus injection of a tracer dose to said mammal, the tracer being substantially intravascular in said tissue,
- b) determining a time series of concentration data being indicative of the concentration of the tracer in arteries of the organ or tissue from the time series of tomographic data,
- c) determining a residue function of the organ or of the part of tissue by deconvolution of the time series of tomographic data with the time series of concentration data,
- d) determining a distribution of transit times from the negative slope of the residue function, and
- e) determining a probability density function (PDF) of a haemodynamic index from the distribution of transit times.
Dependencies are inferred from the claim text.