N-calcium channel knockout animal
AssigneeEisai Research Institute
InventorsMitsuhiro Ino, Norimasa Miyamoto, Eiki Takahashi, Toru Oki, Takashi Yoshinaga, Shinji Hatakeyama, Tetsuhiro Niidome, Kohei Sawada, Yukio Nishizawa, Isao Tanaka
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Abstract
A non-human animal in which a gene coding for the N-type calcium channel is disrupted to lack functional N-type calcium channel, and a method for screening for a substance having a pharmacological action on blood pressure control, transmission of pain, blood sugar level control and so forth by using the animal.
Claims7
A transgenic mouse in which a gene coding for the α1B subunit of the N-type calcium channel is disrupted so that the mouse lacks the functional α1B subunit of the N-type calcium channel, wherein said disruption results in an increased heart rate and blood pressure, decreased transmission of second phase pain or decreased insulin and glucose levels after feeding.
Dependencies are inferred from the claim text.