C1 Inhibitor produced in the milk of transgenic non-human mammals
AssigneePharming Intellectual Property B.V.
InventorsJan Henricus Nuijens, Henricus Antonius Van Veen, Frank Robert Pieper, Joris Jan Heus
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Abstract
The invention provides transgenic nonhuman mammals expressing C1 inhibitor in their milk. The C1 inhibitor is useful in treating patients with hereditary angioedema or patients requiring immunosuppression.
Claims18
A nonhuman mammal whose genome comprises a DNA segment encoding a C1 inhibitor heterologous to the mammal operably linked to at least one expression regulatory sequence from a gene that is preferentially expressed in mammary gland cells and a DNA segment encoding a signal peptide functional in mammary gland cells;
- wherein the DNA segment encoding the C1 inhibitor can be expressed in the mammary gland cells to produce C1 inhibitor in the milk of an adult form of said mammal or a female descendant thereof.
Milk from a nonhuman transgenic mammal whose genome comprises a DNA segment encoding a C1 inhibitor heterologous to the mammal operably linked to at least one expression regulatory sequence from a gene that is preferentially expressed in mammary gland cells and a DNA segment encoding a signal peptide functional in mammary gland cells;
- wherein the DNA segment encoding the C1 inhibitor can be expressed in the mammary gland cells to produce C1 inhibitor in the milk of an adult form of said mammal or a female descendant thereof.
Dependencies are inferred from the claim text.