Caspase 1 gene transfer animal
AssigneesHitoshi Mizutani, Kenji Nakanishi, Taiho Pharmaceutical Co., Ltd.
InventorHitoshi Mizutani
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Abstract
A transgenic rodent or its offspring which carries DNA having an exogenous caspase 1 gene integrated thereinto in such a manner as to express the gene specifically to the skin. The transgenic rodent of the present invention spontaneously develops atopic dermatitis in the absence of any specific pathogenic microorganism and is useful as a disease model animal. The transgenic rodent of the present invention is useful for developing preventive and/or therapeutic drugs for atopic dermatitis based on natural immunity and to clarify the onset mechanism of atopic diseases.
Claims12
A transgenic mouse or an offspring thereof,
- comprising an exogenous caspase 1 gene encoding caspase 1 in somatic cells and germ cells of the transgenic mouse, and wherein the caspase 1 gene is expressed specifically in the skin;
- and,
- wherein the mouse or the offspring exhibits the phenotype of exhibiting at least one symptom of atopic dermatitis selected from the group consisting of erosive dermatitis, skin ulcer, and erosion.
Dependencies are inferred from the claim text.