Preparation of phosphorus-containing compounds useful in the preparation of biphosphine ligands
AssigneeSRI International
InventorsRoelof Van Ginkel, Alexander Van Der Made, Jan De With
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Abstract
This invention relates to processes for making phosphorus compounds R2P—X—PR2, R2P-M, R2P-L and R3P, and the novel cation R2P+(L)-X—P+(L)R2, where R represents an optionally substituted hydrocarbyl group, X represents a bridging group, L represents a leaving group and M represents an alkali metal atom. The invention relates further to a process for making a compound R2P-L from a compound R—H via a new process for making the compound R—Li followed by its reaction with a compound Hal2P-L. The compound R2P—X—PR2 is a ligand suitable for making catalysts for copolymerizing carbon monoxide and a olefinically unsaturated compound.
Claims18
A process comprising:
- lithiating a compound of the formula R1—H, where R1 represents an aryl group substituted by an alkoxy, aryloxy, dialkylamino, dialkylaminoalkyl, dialkylamido, alkoxyalkoxy, alkylthio, alkylsulfonyl, dialkylamidosulfonyl, alkylsulfonate or lithiated hydroxyl group;
- with a compound of the formula Q-Li, where Q represents an alkyl, cycloalkyl, aralkyl or aryl group;
- in a solvent comprising an ether compound of the formula E1-O-E2, where each of E1 and E2 independently represent a substituted alkyl group or a substituted aryl group, and having a boiling point of at least 40° C. at atmospheric pressure.
A process for the preparation of a compound of the formula R13P, where R1 represents an aryl group substituted by an alkoxy, aryloxy, dialkylamino, dialkylaminoalkyl, dialkylamido, alkoxyalkoxy, alkylthio, alkylsulfonyl, dialkylamidosulfonyl, alkylsulfonate or lithiated hydroxyl group, comprising:
- lithiating a compound of the formula R1—H;
- with a compound of the formula Q-Li, where Q represents an alkyl, cycloalkyl, aralkyl or aryl group;
- in a solvent comprising an ether compound of the formula E1-O-E2, where each of E1 and E2 independently represent a substituted alkyl group or a substituted aryl group, and having a boiling point of at least 40° C. at atmospheric pressure;
- and
- reacting the resultant compound R′—Li, without isolation thereof, with phosphorous trichloride.
A process for the preparation of a compound of the formula R2P—Li, comprising reacting a compound of formula R2P-L with lithium, where R is a substituted hydrocarbyl group, and L represents a leaving group.
A process for the preparation of a compound of the formula R12P—Li, comprising reacting a compound of formula R12P-L with lithium, where R1 is a substituted hydrocarbyl group, and L represents a group of formula —NR″2 where each group R″ represents an alkyl group or the groups R″ together constitute an alkylene chain.
A process for the preparation of a compound of the formula R2P—Li, comprising:
- reacting a compound of the formula R1—Li, where R1 represents an aryl group substituted by an alkoxy, aryloxy, dialkylamino, dialkylaminoalkyl, dialkylamido, alkoxyalkoxy, alkylthio, alkylsulfonyl, dialkylamidosulfonyl, alkylsulfonate or lithiated hydroxyl group;
- with a compound of the formula Hal2P-L, where L represents a leaving group and Hal represents a halogen atom;
- in a solvent comprising an ether compound of the formula E1-O-E2, where E1 and E2 independently represent a substituted alkyl group or a substituted aryl group, and having a boiling point of at least 40° C. at atmospheric pressure.
Dependencies are inferred from the claim text.