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US 7,067,673 B2Granted
Process and catalyst for the preparation of acetylpyridines
AssigneeLonza Ltd.
InventorRoderick John Chuck
Life of this patent
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Abstract
A process for the production of acetylopyridines of the formula (1): by reacting a pyridinecarboxylic ester of the formula (II): wherein R1 is C1-6-alkyl, with acetic acid in the gas phase in the presence of a catalyst. The active material of the catalyst is titanium dioxide and at least one alkali or alkaline earth metal oxide, and it is supported on an alumina-silica support having an apparent porosity of at least 50 percent. The process has the advantage of producing only small amounts of by-products (e.g, pyidine).
Claims18
A process for the preparation of an acetylpyridine of the formula:
- comprising reacting a pyridinecarboxylic ester of the formula:
- where R1 is C1-6-alkyl, with acetic acid in the gas phase in the presence of a catalyst whose active material comprises titanium dioxide and at least one alkali or alkaline earth metal oxide, wherein the catalyst comprises an alumina-silica support having an apparent porosity of at least 50 percent.
Dependencies are inferred from the claim text.