Pyridino and pyrimidino pyrazinones

A compound of Formula (I):

• or a pharmaceutically acceptable salt form thereof, wherein:
• A and B are independently CR4 or N, with the proviso that at least one of A and B is N;
• Ar is aryl or heteroaryl, wherein said aryl or heteroaryl is optionally substituted by one or more substituents independently selected from C1–C6 alkyl, C3–C6 cycloalkyl, C4–C7 cycloalkylalkyl, C2–C6 alkenyl, C2–C6 alkynyl, C1–C4 haloalkyl, C1–C4 haloalkoxy, halogen, CN, NO2, OR5, and SR5;
• R1 is H, CN, C1–C4 haloalkyl, NR1cR1d, NR1cCOR1b, COR1b, CONR1cR1d, OR1c, SR1c, C1–C4 alkyl substituted with 0 to 3 R1a, C2–C4 alkenyl substituted with 0 to 3 R1a, C2–C4 alkynyl substituted with 0 to 3 R1a, C3–C6 cycloalkyl substituted with 0 to 3 R1a, or C4–C8 cycloalkylalkyl substituted with 0 to 3 R1a, with the proviso that R1 is not CH2X, wherein X is halogen;
• each R1a is, independently at each occurrence, halogen, CN, N3, NO2, C1–C2 haloalkyl, NR1cR1d, NR1cCOR1b, COR1b, OR1c, SR1c, S(O)R8, or S(O)2R8;
• each R1b is, independently at each occurrence, C1–C4 alkyl, C1–C4 haloalkyl, C3–C6 cycloalkyl, C2–C4 alkenyl, or C2–C4 alkynyl;
• each R1c is, independently at each occurrence, selected from H, C1–C4 alkyl, C1–C4 haloalkyl, C3–C6 cycloalkyl, C2–C4 alkenyl, or C2–C4 alkynyl;
• each R1d is, independently at each occurrence, selected from H, C1–C4 alkyl, C1–C4 haloalkyl, C3–C6 cycloalkyl, C2–C4 alkenyl, or C2–C4 alkynyl;
• R2 is H, C1–C3 haloalkyl, CN, OH, COR2b, SH, SR2b, SO2NHR2c, SO2NR2cR2d, CONHR2c, CONR2cR2d, OCOR2b, OR2b, NR2cR2d, CO2R2b, C1–C4 alkyl substituted with 0 to 3 R2a, C2–C4 alkenyl substituted with 0 to 3 R2a, C2–C4 alkynyl substituted with 0 to 3 R2a, or C3–C6 cycloalkyl substituted with 0 to 3 R2a;
• with the proviso that R2 is not CH2X, wherein X is halogen;
• each R2a is, independently at each occurrence, halogen, CN, N3, NO2, CF3, OR2c, NR2c, NR2cR2d, NR2cCO2R2b, SR2c, SOR8, SO2R8, CO2R2b, CONR2cR2d, COR2b, OCOR2b, NR2cCONR2cR2d, NR2cCO2R2b, OCONR2cR2d, piperidinyl, pyrrolidinyl, piperazinyl, N-methylpiperazinyl, morpholinyl, or thiomorpholinyl;
• each R2b is, independently at each occurrence, C1–C4 alkyl, C1–C4 haloalkyl, C3–C6 cycloalkyl, C4–C12 cycloalkylalkyl, aryl, heteroaryl, aryl-C1–C4 alkyl, or heteroaryl-C1–C4 alkyl;
• each R2c is, independently at each occurrence, H, C1–C4 alkyl, C1–C4 haloalkyl, C3–C6 cycloalkyl, C4–C12 cycloalkylalkyl aryl, heteroaryl, aryl-C1–C4 alkyl, or heteroaryl-C1–C4 alkyl;
• each R2d is, independently at each occurrence, H, C1–C4 alkyl, C1–C4 haloalkyl, C3–C6 cycloalkyl, C4–C12 cycloalkylalkyl aryl, heteroaryl, aryl-C1–C4 alkyl, or heteroaryl-C1–C4 alkyl;
• R3 is OR3c, NR3cR3d, NHR3c, SR3c, SOR8, SO2R8, SO2NHR3c, SO2NR3cR3d, COR3c, CONHR3c, CONR3cR3d, aryl substituted with 0 to 3 R3a, heteroaryl substituted with 0 to 3 R3a, heterocyclyl substituted with 0 to 3 R3f, C1–C10 alkyl substituted with 0 to 3 R3a, C3–C10 alkenyl substituted with 0 to 3 R3a, C3–C10 alkynyl substituted with 0 to 3 R3a, C3–C8 cycloalkyl substituted with 0 to 3 R3a, C4–C12 cycloalkylalkyl substituted with 0 to 3 R3a, C2–C10 alkoxyalkyl substituted with 0 to 3 R3a, C2–C10 thioalkoxyalkyl substituted with 0 to 3 R3a, C5–C10 cycloalkenyl substituted with 0 to 3 R3a, or C6–C10 cycloalkenylalkyl substituted with 0 to 3 R3a, wherein one carbon in any cycloalkyl moiety is optionally replaced with O, S or NR5;
• each R3a is, independently at each occurrence, C1–C10 alkyl, C2–C10 alkenyl, C2–C10 alkynyl, C3–C6 cycloalkyl, halogen, C1–C4 haloalkyl, CN, OR3c, SR3c, S(O)R8, S(O)2R8, COR3b, NHR3cSO2R3b, OC(O)NR3cR3d, N3, OC(O)OR3b, CO2R3c, OC(O)R3b, NR3cCOR3b, N(COR3b)2, NR3cCONR3cR3d, NR3cCO2R3b, NR3cR3d, CONR3cR3d, aryl, heteroaryl, or heterocyclyl;
• each R3b is, independently at each occurrence, C1–C10 alkyl substituted with 0 to 3 R3e, C2–C10 alkenyl substituted with 0 to 3 R3e, C2–C10 alkynyl substituted with 0 to 3 R3e, C3–C8 cycloalkyl substituted with 0 to 3 R3e, C4–C12 cycloalkylalkyl substituted with 0 to 3 R3e, C2–C10 alkoxyalkyl substituted with 0 to 3 R3e, C5–C10 cycloalkenyl substituted with 0 to 3 R3e, or C6–C10 cycloalkenylalkyl substituted with 0 to 3 R3e, wherein one carbon in any cycloalkyl moiety is optionally replaced with O, S or NR5;
• each R3c is, independently at each occurrence, H, C1–C10 alkyl substituted with 0 to 3 R3e, C2–C10 alkenyl substituted with 0 to 3 R3e, C2–C10 alkynyl substituted with 0 to 3 R3e, C3–C8 cycloalkyl substituted with 0 to 3 R3e, C4–C12 cycloalkylalkyl substituted with 0 to 3 R3e, C2–C10 alkoxyalkyl substituted with 0 to 3 R3e, C5–C10 cycloalkenyl substituted with 0 to 3 R3e, or C6–C10 cycloalkenylalkyl substituted with 0 to 3 R3e, wherein one carbon in any cycloalkyl moiety is optionally replaced with O, S or NR5;
• each R3d is, independently at each occurrence, H, C1–C10 alkyl substituted with 0 to 3 R3e, C2–C10 alkenyl substituted with 0 to 3 R3e, C2–C10 alkynyl substituted with 0 to 3 R3e, C3–C8 cycloalkyl substituted with 0 to 3 R3e, C4–C12 cycloalkylalkyl substituted with 0 to 3 R3e, C2–C10 alkoxyalkyl substituted with 0 to 3 R3e, C5–C10 cycloalkenyl substituted with 0 to 3 R3e, or C6–C10 cycloalkenylalkyl substituted with 0 to 3 R3e, wherein one carbon in any cycloalkyl moiety is optionally replaced with O, S or NR5;
• each R3e is, independently at each occurrence, C1–C6 alkyl, C2–C6 alkenyl, C2–C10 alkynyl, C3–C6 cycloalkyl, halogen, C1–C4 haloalkyl, CN, OR7a, SR7a, S(O)nR8, COR6, CO2R7a, OC(O)R6, NR7aCOR6, N(COR6)2, NR7aCONR7aR7b, NR7aCO2R6, NR7aR7b, NHR7aSO2R6, OC(O)NR7aR7b, N3, OC(O)OR6, CONR7aR7b, aryl, heteroaryl, or heterocyclyl;
• each R3f is, independently at each occurrence, oxo, sulfido, or R3a;
• R4 is H, halogen, CN, C1–C3 haloalkyl, COR4b, OR4c, SR4c, SO2NHR4c, SO2NR4cR4d, CONHR4c, CONR4cR4d, OCOR4b, NR4cCONHR4c, NR4cCONR4cR4d, NR4cCO2R4b, OCONR4cR4d, NR4cR4d, CO2R4b, C1–C4 alkyl substituted with 0 to 1 R4a, C2–C4 alkenyl substituted with 0 to 1 R4a, C2–C4 alkynyl substituted with 0 to 1 R4a, C3–C6 cycloalkyl substituted with 0 to 1 R4a, piperidinyl, pyrrolidinyl, piperazinyl, N-methylpiperazinyl, morpholinyl, or thiomorpholinyl;
• each R4a is, independently at each occurrence, halogen, CN, CF3, OR4c, NHR4c, NR4cR4d, NR4cCO2R4b, SR4c, SOR8, SO2R8, CO2R4b, CONHR4c, CONR4cR4d, COR4b, OCOR4b, NR4cCONR4cR4d, NR4cCO2R4b, OCONR4cR4d, piperidinyl, pyrrolidinyl, piperazinyl, N-methylpiperazinyl, morpholinyl, or thiomorpholinyl;
• each R4b is, independently at each occurrence, C1–C4 alkyl, C1–C4 haloalkyl, C3–C6 cycloalkyl, C4–C12 cycloalkylalkyl, aryl, heteroaryl, aryl-C1–C4 alkyl, or heteroaryl-C1–C4 alkyl;
• each R4c is, independently at each occurrence, H, C1–C4 alkyl, C1–C4 haloalkyl, C3–C6 cycloalkyl, C4–C12 cycloalkylalkyl, aryl, heteroaryl, aryl-C1–C4 alkyl, or heteroaryl-C1–C4 alkyl;
• each R4d is, independently at each occurrence, H, C1–C4 alkyl, C1–C4 haloalkyl, C3–C6 cycloalkyl, C4–C12 cycloalkylalkyl, aryl, heteroaryl, aryl-C1–C4 alkyl, or heteroaryl-C1–C4 alkyl;
• R5 is H, C1–C4 alkyl, C1–C4 haloalkyl, C2–C6 alkenyl, C2–C6 alkynyl, C3–C6 cycloalkyl, C4–C7 cycloalkylalkyl, or C2–C6 alkoxyalkyl;
• R6 is, independently at each occurrence, C1–C6 alkyl, C1–C6 haloalkyl, C2–C6 alkenyl, C2–C6 alkynyl, C3–C6 cycloalkyl, C4–C12 cycloalkylalkyl, C2–C8 alkoxyalkyl, C5–C12 bis(alkoxy)alkyl, aryl, aryl-C1–C4 alkyl, heteroaryl, or heteroaryl-C1–C4 alkyl;
• each R7a is, independently at each occurrence, H, C1–C6 alkyl, C1–C6 haloalkyl, C2–C6 alkenyl, C2–C6 alkynyl, C3–C6 cycloalkyl, C4–C12 cycloalkylalkyl, C2–C8 alkoxyalkyl, C5–C12 bis(alkoxy)alkyl, aryl, aryl-C1–C4 alkyl, heteroaryl, or heteroaryl-C1–C4 alkyl;
• each R7b is, independently at each occurrence, H, C1–C6 alkyl, C1–C6 haloalkyl, C2–C6 alkenyl, C2–C6 alkynyl, C3–C6 cycloalkyl, C4–C12 cycloalkylalkyl, C2–C8 alkoxyalkyl, C5–C12 bis(alkoxy)alkyl, aryl, aryl-C1–C4 alkyl, heteroaryl, or heteroaryl-C1–C4 alkyl;
• and
• R8 is C1–C4 alkyl, C1–C4 haloalkyl, C3–C6 cycloalkyl, C4–C12 cycloalkylalkyl, aryl, heteroaryl, aryl-C1–C4 alkyl, or heteroaryl-C1–C4 alkyl, or NR7aR7b.