Antibody or antibody fragments specific for a protein of the TGF-β family
AssigneeBiopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH
InventorsGertrud Hötten, Helge Neidhardt
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Abstract
The invention provides antibody and antibody fragments which specifically bind to novel members of the TGF-β family of proteins. The TFG-β family comprises proteins which function as growth and/or differentiation factors and which are useful in medical applications. Accordingly, the invention also applies to the production of said antibodies or antibody fragments and a diagnostic method for detecting said proteins of the TGF-β family.
Claims8
An antibody or antibody fragment which specifically binds to a protein of the TGF-β family wherein said antibody or antibody fragment binds to a part of the protein encoded by nucleotide sequence selected from the following group:
- (a) the nucleotide sequence as shown in SEQ ID NO:
- 1,
- (b) a nucleotide sequence which is degenerate as a result of the genetic code to the nucleotide sequence of (a), and
- (c) fragments of (a) or (b) which encode a protein which has the cartilage or bone inducing activities of a mature protein encoded by the nucleotide sequence of SEQ ID NO:1.
A kit for detecting a protein of the TGF-β family, comprising
- an antibody or antibody fragment which specifically binds to a protein of the TGF-βfamily, and
- a reaction buffer,
- wherein said antibody or antibody fragment binds to a part of the protein which is encoded by a nucleotide sequence selected from the following group:
- (a) the nucleotide sequence as shown in SEQ ID NO:1,
- (b) a nucleotide sequence which is degenerate to the nucleotide sequence of (a) as a result of the degeneracy of the genetic code, and
- (c) fragments of (a) or (b) which encode a protein which has the cartilage or bone inducing activities of a mature protein encoded by the nucleotide sequence of SEQ ID NO:1.
An isolated antibody or antibody fragment which specifically binds to a protein of the TGF-β family wherein said antibody or antibody fragment binds to a fragment of SEQ ID NO:3, wherein said fragment of SEQ ID NO:3 comprises the amino acids shown in SEQ ID NO:22.
An isolated antibody or antibody fragment which specifically binds to a protein of the TGF-β family wherein said antibody or antibody fragment binds to a part of the protein encoded by a nucleotide sequence selected from the following group:
- (a) the nucleotide sequence as shown in SEQ ID NO:1,
- (b) a nucleotide sequence which is degenerate to the nucleotide sequence of (a) as a result of the degeneracy of the genetic code, and
- (c) fragments of (a) or (b) which encode a protein which retains the cartilage or bone inducing activities of the protein encoded by the nucleotide sequence of SEQ ID NO:1.
An isolated antibody or antibody fragment which specifically binds to a protein of the TGF-β family, wherein said protein is selected from the following group:
- (a) a protein encoded by DNA consisting of the nucleotide sequence as shown in SEQ ID NO:1,
- (b) a protein encoded by a DNA consisting of a fragment of the nucleotide sequence as shown in SEQ ID NO:1, wherein said fragment of SEQ ID NO:1 comprises the nucleotide sequence as shown in SEQ ID NO:
- 6,
- (c) a protein encoded by DNA consisting of a nucleotide sequence which is degenerate to the nucleotide sequence of (a) as a result of the degeneracy of the genetic code or (b),
- (d) a protein consisting of the amino acid sequence shown in SEQ ID NO:3, and
- (e) a protein consisting of a fragment of the amino acid sequence shown in SEQ ID NO:
- 3, wherein said fragment of SEQ ID NO:3 comprises the amino acid sequence shown in SEQ ID NO:22.
Dependencies are inferred from the claim text.