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US 7,067,629 B2Granted
Sodium channel in dorsal root ganglia
AssigneeYale University
InventorsSulayman Dib-Hajj, Stephen G. Waxman
Life of this patent
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Abstract
A novel tetrodotoxin resistant sodium channel is described, along with isolated nucleotides that encode this receptor. Methods for identifying agents that modulate the Na+ current through the receptor are provided, as well as related therapeutic and diagnostic methods.
Claims19
An isolated protein capable of producing a sodium current and encoded by a nucleic acid with at least 80% sequence identity to a nucleotide sequence comprising SEQ ID NO:
- 41.
An isolated protein comprising an amino acid sequence of SEQ ID NO:
- 42 or a peptide fragment thereof capable of producing a sodium current.
An isolated protein comprising an amino acid sequence of SEQ ID NO:
- 42.
Dependencies are inferred from the claim text.