Volatilizable solid phase supports for compound synthesis
AssigneeMixture Sciences, Inc.
InventorsJeanick H. Pascal, Michael J. Moran, Richard A. Houghten
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Abstract
A solid phase synthetic method is disclosed in which the usual solid phase synthetic steps are carried out and the spent solid phase support is reacted to form a volatilizable compound upon cleavage of the reaction product from the solid phase support. The cleaved product is then separated from the volatile compound by volatilization of that compound. Exemplary solid supports that form a volatilizable compound are also disclosed.
Claims8
In a solid phase synthesis method wherein at least one reagent coupled to said solid phase support is a heterocycle, a plurality of reactions are carried out upon the solid phase-coupled heterocycle to form a solid phase-coupled reaction product and that reaction product is cleaved from the solid phase support to form a cleaved product, the improvement in which the solid phase support is converted to a volatile compound that is separated from the cleaved product by vaporization of said volatile compound, leaving behind said cleaved product.
Dependencies are inferred from the claim text.