Medicinal preparations
AssigneeKyowa Hakko Kogyo Co., Ltd.
InventorsYasuki Kato, Hiroko Kusano, Yuji Kawaguchi, Kunio Ito
Life of this patent
Estimating the term…
Abstract
The present invention provides a pharmaceutical preparation comprising a compound which can be obtained by reacting a compound having a free amino group with a sugar having the reducing power. The preparation is capable of improving the in vivo durability of various compounds and releasing the compounds in response to changes in pH, and thus is useful for causing the compounds to act specifically on target parts.
Claims21
A pharmaceutical preparation comprising a compound (I), which is obtained by reacting a peptide (II) having a free amino group, with a sugar (III) having reducing power and selected from group A, wherein said peptide is a pharmaceutical compound,
- wherein group A consists of lactose, sialyllactose and compounds prepared by chemically binding a polymer from the group consisting of polyoxyethylene, polyglutamic acid and polyvinylpyrrolidone to a hydroxyl group other than the hydroxyl group formed from the reducing aldehyde group of lactose and sialyllactose,
- wherein an amino group of said peptide (II) reacts with an aldehyde group in said sugar (III);
- and
- wherein said compound (I) can release said peptide (II) having a free amino group in response to changes in pH.
Dependencies are inferred from the claim text.