Method for the synthesis of compounds of formula I and their uses thereof

A compound comprising at least one moiety of the formula

• wherein L1 is a C1–C4 alkyl group and L2 is a direct bond, and Aryl1 and Aryl2 are aryl, wherein each of Aryl1 and Aryl2 are substituted by at least one lipophilic group selected from the group consisting of
• a) —Y—C16 alkyl;
• b) —Y-aryl;
• c) —Y—C-1-6 alkylaryl;
• d) —Y—C1-6-alkyl-NR7R8;
• e) —Y—C1-6-alkyl-W—R20;
• wherein
• Y and W are, independently selected from the group consisting of —CH2—, —O—, —N(H), —S—, SO2—, —CON(H)—, —NHC(O)—, —NHCON(H)—, —NHSO2—, —SO2N(H)—, —C(O)—O—, —NHSO2NH—, —O—CO—,
• and
• f) halogen, hydroxyl, cyano, carbamoyl, and carboxyl;
• wherein
• R18 and R19 are independently selected from the group consisting of aryl, C1–C6 alkyl, C1–C6 alkylaryl, C1–C6 alkoxy, and C1–C6 alkoxyaryl;
• R20 is selected from the group consisting of aryl, C1–C6 alkyl, and C1–C6 alkylaryl;
• R7, R8, R9 and R10 are independently selected from the group consisting of hydrogen, aryl, C1–C6 alkyl, and C1–C6 alkylaryl;
• and wherein R7 and R8 may be taken together to form a ring having the formula —(CH2)m—X—(CH2)n bonded to the nitrogen atom to which R7 and R8 are attached, wherein m and n are, independently, 1, 2, 3, or 4;
• X is selected from the group consisting of —CH2—, —O—, —S—, —S(O2)—, —C(O)—, —CON(H)—, —NHC(O)—, —NHCON(H)—, —NHSO2—, —SO2N(H)—, —C(O)—O—, —O—C(O)—, —NHSO2NH—,
• or a pharmaceutically acceptable salt thereof,
• wherein at least one of Aryl1 and Aryl2 is substituted with a lipophilic group of the formula —Y—C1-6-alkyl-NR7R8.