Crystal and process for producing the same
AssigneeTakeda Pharmaceutical Company Limited
InventorsHideo Hashimoto, Hideaki Maruyama
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Abstract
A process for producing crystals of 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl) biphenyl-4-yl]methyl]-1H-benzimdazole-7-carboxylic acid (compound (I)), characterized by dissolving or suspending the compound (I) or a salt thereof in a solvent comprising an aprotic polar solvent and crystallizing it. By the process, the contaminants which are contained in the compound (I) or its salt and are difficult to remove, such as tin compounds, analogues of the compound (I), and a residual organic solvent, can be easily removed. Crystals of the compound (I) can be efficiently and easily mass-produced in high yield on an industrial scale.
Claims10
A process for producing a crystal of 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid, which comprises crystallizing from a solution or suspension containing 2-ethoxy-1-[[2′-(1H-tetrazol5-yl) biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid or a salt thereof and an aprotic polar solvent, wherein the aprotic polar solvent is tetrahydrofuran, dimethylformamide, dimethyl sulfoxide, hexamethylphosphoric triamide, or a mixed solvent of two or more of them.
A process for producing a crystal of 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl) biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid, which comprises crystallizing from a solution containing 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid and an aprotic polar solvent, wherein the aprotic polar solvent is tetrahydrofuran, dimethylformamide, dimethyl sulfoxide, hexamethylphosphoric triamide, or a mixed solvent of two or more of them.
Dependencies are inferred from the claim text.