4-,6- or 7-hydroxyindoles with N-oxide groups and the use thereof as therapeutic agents

A compound of formula 1

• wherein
• R1
• (i) is —C1-10-alkyl, straight-chain or branched-chain, optionally mono- or polysubstituted by mono-, bi- or tricyclic saturated or mono- or polyunsaturated carbocycles with 3–14 ring members,
• wherein the carbocyclic substituents in turn are substituted one or more times by —NO2 and may optionally be substituted one or more times by —C1-6-alkyl, —OH, —NH2, —NHC1-6-alkyl, —N(C1-6-alkyl)2, —NO2, —CN, —F, —Cl, —Br, —I, —O—C1-6-alkyl, —S—C1-6-alkyl, —SO3H, —SO2C1-6-alkyl, —OSO2C1-6-alkyl, —COOH, —(CO)C1-5-alkyl, —COO—C1-5-alkyl or/and —O(CO)C1-5-alkyl, and wherein the alkyl groups on the carbocyclic substituents in turn may optionally be substituted one or more times by —OH, —SH, —NH2, —F, —Cl, —Br, —I, —SO3H or/and —COOH,
• R2 is hydrogen or —C1-3-alkyl,
• R3, R4 and R5 are hydrogen or a hydroxyl group, wherein at least one of these substituents must be a hydroxyl group,
• R6 and R7 may be identical or different and are hydrogen, —C1-6-alkyl, —OH, —SH, —NH2, —NHC1-6-alkyl, —N(C1-6-alkyl)2, —NO2, —CN, —SO3H, —SO3—C1-6-alkyl, —COOH, —COO—C1-6-alkyl, —O(CO)—C1-5-alkyl, —F, —Cl, —Br, —I, —O—C1-6-alkyl, —S—C1-6-alkyl, -phenyl or -pyridyl, wherein the phenyl or pyridyl substituents in turn may optionally be substituted one or more times by —C1-3-alkyl, —OH, —SH, —NH2, —NHC1-3-alkyl, —N(C1-3-alkyl)2, —NO2, —CN, —SO3H, —SO3C1-3-alkyl, —COOH, —COOC1-3-alkyl, —F, —Cl, —Br, —I, —O—C1-3-alkyl, —S—C1-3-alkyl, or/and —O(CO)C1-3-alkyl, and wherein the alkyl substituents in turn may optionally be substituted one or more times by —OH, —SH, —NH2, —F, —Cl, —Br, —I, —SO3H, —SO3C1-3-alkyl, —COOH, —COOC1-3-alkyl, —O—C1-3-alkyl, —S—C1-3-alkyl or/and —O(CO)—C1-3-alkyl,
• or a salt of the compounds of formula 1.