Aminophenoxyacetamide derivatives and pharmaceutical composition containing thereof

An aminophenoxyacetamide derivative represented by the following formula (I):

• wherein:
• R1, R2, R3 and R4 are, independent from each other, hydrogen atom or lower alkyl group;
• R5 R6 R7 and R8 are, independent from each other, hydrogen atom or lower alkyl group;
• E1 is group —NR9— (in which, R9 is hydrogen atom or lower alkyl group);
• E2 is oxygen atom or group —NR10— (in which, R10 is hydrogen atom or lower alkyl group which may be substituted);
• Q is a group of —X—Y-Q′, wherein X is a connecting bond, lower alkyl group, lower alkenyl group, or lower alkenyl group;
• Y is a connecting bond, or a group selected from the groups consisting of C═O, C(═O)NH, NHC(═O), —O—, —S—, CH(OH), —O—CH(OH)— and —O—CH2—CH(OH)—, in which hydrogen atom of amido group may be substituted with lower alkyl group;
• and Q′ is hydrogen atom or a cyclic group selected from the group consisting of phenyl group, pyridily group, ciuinolyl group, isociuinolyl group, benzothiazole group, benzimidazole group, morpholinyl group, and cyclic hydrocarbon group, wherein one or more of the hydrogen atoms in the cyclic group of Q′ may be substituted;
• either in the case that E2 is the group —NR— then X and Y are both connecting bond and Q′ is not hydrogen atom;
• or in the case that E2 is the group —O— then all of the groups R1, R2, R3 and R4 are methyl group;
• or a pharmaceutically acceptable salt thereof,
• where Q′ is a cyclic hydrocarbon group and said cyclic hydrocarbon group is cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl.

An aminophenoxyacetamide derivative represented by the following formula (I):

• wherein:
• R1, R2, R3 and R4 are, independent from each other, hydrogen atom or lower alkyl group;
• R5 R6 R7and R8are, independent from each other, hydrogen atom or lower alkyl group;
• E1 is group —NR9— (in which, R9 is hydrogen atom or lower alkyl group);
• E2 is oxygen atom or group —NR10— (in which, R10 is hydrogen atom or lower alkyl group which may be substituted);
• Q is a group of —X—Y-Q′, wherein X is a connecting bond, lower alkyl group, lower alkenyl group, or lower alkenyl group;
• Y is a connecting bond, or a group selected from the groups consisting of C═O, C(═O)NH, NHC(═O), —O—, —S—, CH(OH), —O—CH(OH)— and —O—CH2—CH(OH)—, in which hydrogen atom of amido group may be substituted with lower alkyl group;
• and Q′ is hydrogen atom or a cyclic group selected from the group consisting of phenyl group, pyridily group, ciuinolyl group, isociuinolyl group, benzothiazole group, benzimidazole group, morpholinyl group, and cyclic hydrocarbon group, wherein one or more of the hydrogen atoms in the cyclic group of Q′ may be substituted;
• either in the case that E2 is the group —NR10— then X and Y are both connecting bond and Q′ is not hydrogen atom;
• or in the case that E2 is the group —O— then all of the groups R1 R2, R3 and R4 are methyl group;
• or a pharmaceutically acceptable salt thereof, wherein Q′ is an unsaturated or saturated heterocyclic group and said unsaturated or saturated heterocyclic group is morpholinyl.