Back to results
US 7,067,530 B2Granted
Compounds, their preparation and use
AssigneeNovo Nordisk A/S
InventorsLone Jeppesen, Paul Stanley Bury, John Patrick Mogensen, Ingrid Pettersson, Per Sauerberg
Life of this patent
Estimating the term…
Abstract
Novel compounds of general formula (I), the use of these compounds as medicaments, pharmaceuticaly compositions comprising the compounds and methods of treatment employing these compounds and compostiones. The present compounds may be useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR). The compounds exert their effects by modulating the PPARγ response in a partial agonist manner.
Claims21
A compound of formula (I)
- wherein X is biphenyl, a fused polycyclic hydrocarbon, or heteroaryl, each of which is optionally substituted with one or more substituents selected from the group consisting of:
- halogen, perhalomethyl, perhalomethoxy, hydroxy, cyano, amino, C1-6-alkylamino, C3-6-cycloalkylamino, C1-6-dialkylamino, or carboxy;
- C1-6-alkyl, C3-6-cycloalkyl, C2-6-alkenyl, C2-6-alkynyl, C1-6-alkoxy, C3-6-cycloalkoxy, C1-6-alkylthio, or C3-6-cycloalkylthio, each of which is optionally substituted with halogen;
- and wherein
- Y is H, C1-6-alkyl, C3-6-cycloalkyl, C2-6-alkenyl, C2-6-alkynyl, or C4-6-alkenynyl;
- and
- R1 is hydrogen or halogen;
- or
- R1 is C1-6-alkyl, C3-6-cycloalkyl, C1-6-alkoxy or C3-6-cycloalkoxy, each of which is optionally substituted with one or more substituents selected from the group consisting of halogen, hydroxy, and cyano;
- and
- R2 and R3 are independently hydrogen, halogen, C1-6-alkyl or C3-6-cycloalkyl;
- and
- R4 is hydrogen, C1-6-alkyl or C3-6-cycloalkyl;
- or
- a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, or any tautomeric forms, stereoisomers, mixture of stereoisomers including a racemic mixture, or polymorphs.
12 more elements
Dependencies are inferred from the claim text.