Glutamine fructose-y-phosphate amidotransferase (GFAT) inhibitors

A compound of formula (I):

• wherein
• R1 is -lower alkyl, —CH2-aryl, -cycloalkyl, —(CH2)3—OC(═O)CH3, -lower alcohol, -lower alkyl-R10, —CH2COOH, or —CH2CH2OCH2CH3;
• R2 is -lower alkyl, —CH2-aryl, -lower alcohol, —CH2C(═O)NH2, or -lower alkyl-R10, wherein at least one of R1 or R2 is —CH3;
• R3 is —COOH, -lower alkyl-COOH, -lower alcohol, —CH2OCH3, —CH2NH2, —CH2NHSO2R11, —C(═O)R12, —CNHCH2CH2—R12, —C(═NH)—R12, —(CH2)nNHC(═O)R13, —(CH2)mC(═O)N(R15)(R16), —C(═NH)—R17, or —(CH2)n—R18;
• R4 is —H, -lower alkoxy, —O—C(R7R8)C(═O)R19, -halo, —SCH3, —C═CHC(═O)—R10, —CH2CH2C(═O)—R10, —O-lower alcohol, —OCH2CH(OH)CH2N═N+N−, —OCH2CH2OCH2CH2Cl, —NHC(═O)CH2—R10, —NHC(═O)CH2-lower alkyl, —O(CH2)n-cycloalkyl, —O-lower alkene, or a 5 membered unsaturated heterocyclic ring containing one hetero atom which is S or O;
• R5 and R6 are each independently —H, -halo or -lower alkoxy;
• R7 and R8 are each independently —H or —CH3,
• R10 is a 5 or 6 membered saturated heterocyclyl containing 1 or 2 heteroatoms, wherein each hetero atom is selected from N and O, and the group is bound to the remainder of the molecule at a ring N;
• R11 is —CF3, -lower alkyl, —CH2Cl, —CH2CF3, or —R12;
• R12 is a 5 or 6 membered saturated substituted or unsubstituted heterocyclic ring containing one hetero atom which is selected from N, O, and S wherein the substituted ring is the heterocyclic ring substituted with —OH or -phenyl;
• R13 is -lower alkyl, -lower alkoxy, or —(CH2)nR14;
• R14 is a 5 or 6 membered saturated or unsaturated heterocyclic ring containing one or two hetero atoms which are selected from N and O;
• R15 is —H or —CH3;
• R16 is —H, -lower alkyl, —C≡N, —OH, -lower alkoxy, or —CH2COOCH2CH3;
• R17 is -lower alkoxy —NH2 or —N-lower alkyl;
• R18 is a saturated or unsaturated 5 membered substituted or unsubstituted heterocyclic ring containing from 1 to 4 hetero atoms wherein the hetero atoms are selected from N, O and S, wherein the substituted ring is the heterocyclic ring which is substituted at one or two ring carbons with ═O, or substituted at a ring N with -lower alcohol or -lower alkyl;
• R19 is —OH, —NHCH(CH3)2, —N(CH3)CH2-aryl, —N(CH3)-lower alkyl,
• or 5 or 6 membered saturated substituted or an unsubstituted heterocyclyl containing 1 or 2 heteroatoms wherein each heteroatom is independently selected from N, O and S, wherein said substituted heterocyclyl is the heterocyclyl substituted with lower alkyl;
• m is 0, 1 or 2;
• n is 0 or 1;
• and pharmaceutically acceptable salts and esters thereof.