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US 7,067,518 B2Granted
Pyridinyl-methyl-ethyl cyclohexanecarboxamides as serotonergic agents
AssigneeWyeth
InventorsLynne P. Greenblatt, Michael G. Kelly, Yvette L. Palmer
Life of this patent
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Abstract
A compound having 5-HT1A receptor activity, represented by the chemical formula wherein: Ar is 2-methoxyphenyl, 1H-indol-4-yl or 2,3-dihydro-1,4-benzodioxin-5-yl; R1 is 2-, 3- or 4-pyridyl; R2 is H or C1-6alkyl; R3 is H or C1-6alkyl; and R4 is H or methyl, or an optical isomer thereof, or a pharmaceutically acceptable salt of such a compound or optical isomer. The invention also includes compositions containing such a compound, as well as methods for using a compound of the invention.
Claims11
A compound according to the formula
- wherein:
- Ar is selected from the group consisting of 2-methoxyphenyl, 1H-indol-4-yl and 2,3-dihydro-1,4-benzodioxin-5-yl;
- R1 is 2-, 3- or 4-pyridyl;
- R2 is H or C1-6 alkyl;
- R3 is H or C1-6 alkyl;
- and
- R4 is H or C1-6 alkyl,
- or an optical isomer thereof,
- or a pharmaceutically acceptable salt of said compound or optical isomer thereof.
6 more elements
Dependencies are inferred from the claim text.