Serine protease inhibitors

A tryptase inhibitor compound of formula (I)

• where:
• R5 represents amino, hydroxy, aminomethyl, hydroxymethyl or hydrogen;
• R6a represents hydrogen or methyl;
• X—X is selected from the group consisting of —CH═CH—, —CONR1a—, —NH—CO—, —NR1a—CH2—, —CH2—NR1a—, —CH2O—, —OCH2—, —COO—, —OC═O— and —CH2CH2—;
• R1a represents hydrogen, (1–6C)alkyl or phenyl(1–6C)alkyl;
• L is CONR1d(CH2)m in which m is 0 or 1 and R1d is hydrogen, (1–6C)alkyl or phenyl(1–6C)alkyl;
• Cy is a saturated or unsaturated, mono or poly cyclic, homo or heterocyclic group optionally substituted by one or more groups R3a — or R3iXi—;
• each R3a independently is hydrogen, hydroxyl, (1–6C) alkoxy, (1–6C)alkyl, (2–6C)alkenyl, (2–6C)alkynyl, (1–6C)alkanoyl, (1–6C)alkylaminoalkyl, hydroxy(1–6C)alkyl, carboxy, (1–6C)alkoxyalkyl, (1–6C)alkoxycarbonyl, (1–6C) alkylaminocarbonyl, amino (1–6C)alkyl, CONH2, CH2CONH2, aminoacetyl, (1–6C)alkanoylamino, hydroxy(1–6C) alkanoylamino, amino(1–6C)alkanoylamino, (1–6C)alkylamino(1–6C) alkanoylamino, di(1–6C)alkylamino(1–6C)alkanoylamino, (1–6C) alkoxycarbonylamino, amino, halo, cyano, nitro, thiol, (1–6C) alkylthio, (1–6C) alkylsulphonyl, (1–6C) alkylsulphenyl, imidazolyl, hydrazido, (16C)alkylimidazolyl, (1–6C) alkylsulphonamido, (1–6C) alkylaminosulphonyl, aminosulphonyl, (1–6C) haloalkoxy, or (1–6C)haloalkyl;
• Xi is a bond, O, NR1p, CH2, CO, CONR1p, R1pCO, SO2, NR1pSO2 or SO2NR1p;
• R3i is phenyl or pyridyl;
• R1i is as defined for R1a
• Lp is selected from the group consisting of
• in which R3 is an amino acid residue, N-(1–6C)alkylaminocarbonyl, N,N-di (1–6C)alkylaminocarbonyl, N-(1–6C)alkylaminoalkanoyl, N-(1–6C) alkanoylamino(1–6C)alkanonyl, C-hydroxyamino(1–6C)alkanoyl, hydroxy(2–6C)alkanoylamino(1–6C)alkanoyl, di(1–6C)alkylaminosulfonyl, hydrogen, hydroxyl, (1–6C)alkoxy, (1–6C)alkanoyloxy, (1–6C) alkyl, (2–6C)alkenyl (2–6C)alkynyl, (3–6C)alkenyloxycarbonyl, (1–6C)alkanoyl, amino(1–6C)alkyl, amido (CONH2), amino(1–6C)alkanoyl, aminocarbonyl (1–50) alkanoyl, hydroxy(1–6C) alkyl, carboxy, hydroxy(1–6C)alkanoyl, (1–6C)alkoxy(1–6C)alkanoyl, (1–6C)alkoxy(1–6C)alkyl, (1–6C)alkoxycarbonyl(1–5C)alkyl, (1–6C)alkoxycarbonyl, (1–6C)alkanoylamino, amino, halo, cyano, nitro, thiol, (1–6C) alkylthio, (1–6C)alkylsulfonyl, (1–6C)alkylsulphenyl or hydrazido;
• R3y represents R3 or a group of formula
• Rk-G2-Xa—
• in which G2 is absent or represents (1–3C)alkanediyl, Xa is absent or represents O, S, SO, SO2 NRL, CO, OCO, COO, CONRL, NRLCO, SO2NRL or NRLSO2;
• Rk represents a carbocyclic or heterocyclic group, optionally substituted by R3;
• and RL represents hydrogen or (1–6C)alkyl;
• R3z is oxo or is as defined for R3y, Xza is CR2 and Xz is O, S or NRz in which Rz has a value independently selected from a value for R3y;
• or a physiologically tolerable salt thereof.