US 7,067,508 B2 · Diaminedithiol derivatives and radiorhenium or radiotechnetium complex thereof; a liver cancer-treating composition comprising the radiorhenium complex and lipiodol; and a kit for preparation of the liver cancer-treating composition

Abstract

The present invention relates to a novel diaminedithiol derivative or a pharmaceutically acceptable salt thereof; radiorhenium or radiotechneticum complex thereof; a composition for treating liver cancer comprising the radiorhenium complex and lipiodol; and, a preparative kit of the composition for treating liver cancer. In the composition according to the invention, the diaminedithiol derivative is a novel compound in which long chain alkyl groups were introduced to diaminedithiol, capable of forming a radiorhenium or radiotechnetium complex thereof with an ease and leading to stronger van der Waals bonds with lipiodol. As a result, the complex becomes more stable in a medium, lipiodol, whereby the composition of the invention exhibits a high accumulation rate in liver cancer tissue when injected via hepatic artery, thereby capable of achieving an efficient treatment of liver cancer.

Claims13

Dependent claims

A diaminedithiol derivative of Formula 2 or a pharmaceutically acceptable salt thereof:

wherein:
R2, R3, R8 to R14 are independently hydrogen or lower alkyl having C1 to C5;
R4 and R5 are independently hydrogen or lower alkyl having C1 to C5 or they form oxo (═O) group;
R6 and R7 are independently hydrogen or lower alkyl having C1 to C5 or they form oxo (═O) group, in which at least one of R2 to R14 is higher alkyl having C15 to C24 and R4 to R7 don't form two oxo (═O) groups at the same time;
R1 and R15 are independently hydrogen or thiol protecting group such as benzoyl, acetamidomethyl, diphenylmethyl, ethylaminocarbonyl, t-butyl, trityl and acetyl, or R1 and R15 together form a S—S bond;
and,
n, o, p are independently 1 or 2.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application

10/469,198Filed 8 Mar 2002

Priority

KR 2001-1398719 Mar 2001

Published

US 2004/0087567 A16 May 2004

Granted

27 Jun 2006

Term ends

Not estimatedThe source records don’t support an estimate.

Classification10 codes

C07D 285/00
Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only
A61P 35/00
Antineoplastic agents
C07C 323/41
Y being a hydrogen or a carbon atom: y being a hydrogen or an acyclic carbon atom
C07F 13/005
Compounds containing elements of Groups 7 or 17 of the Periodic Table: compounds without a metal-carbon linkage

Diaminedithiol derivatives and radiorhenium or radiotechnetium complex thereof; a liver cancer-treating composition comprising the radiorhenium complex and lipiodol; and a kit for preparation of the liver cancer-treating composition

Life of this patent

Diaminedithiol derivatives and radiorhenium or radiotechnetium complex thereof; a liver cancer-treating composition comprising the radiorhenium complex and lipiodol; and a kit for preparation of the liver cancer-treating composition

Life of this patent

Abstract

Claims13