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US 7,067,503 B2Granted
17-aryl linker derivatised estrogen 3-sulphamates as inhibitors of steroid sulphatase
AssigneeSterix Limited
InventorsBarry Victor Lloyd Potter, Michael John Reed, Bertrand Leblond, Matthew Paul Leese
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Abstract
There is provided a compound comprising a steroidal ring system and a group R1 selected from any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein the D ring of the steroidal ring system is substituted by a group R2 of the formula —L-R3, wherein L is an optional linker group and R3 is an aromatic hydrocarbyl group.
Claims27
A compound of Formula IV
- wherein R1 is selected from any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group;
- wherein group R2 is of the formula L-R3, wherein L is an optional linker group and R3 is an aromatic hydrocarbyl group, and wherein the A ring of the steroidal ring system is substituted with a group R4, wherein R4 is a hydrocarbyl group.
Dependencies are inferred from the claim text.