Aryloxyphenyl and arylsulfanylphenyl derivatives

A compound represented by the general formula I

• wherein
• Y is N;
• X represent O or S;
• m is 1;
• p is 0, 1, 2, 3 or 4;
• q is 0, 1 or 2;
• s is 0, 1, 2 or 3;
• r is 0, 1 or 2;
• Q represents C, P—OR5, or S═O, wherein R5 hydrogen or C1-6-alkyl;
• A is OR6, wherein R6 represent hydrogen, C1-6-alkyl, aryl or aryl-C1-6-alkyl, wherein aryl may be substituted with halogen, CF3, OCF3, CN, NO2 or C1-6 alkyl;
• AR represents phenyl;
• each R4 individually represents C1-6-alkyl, C3-8-cycloalkyl or C3-8-cycloalkyl-C1-6-alkyl;
• each R1 is independently selected from the group consisting of C1-6-alkyl, or two R1 attached to the same carbon atom may form a 3–6-membered spiro-attached cycloalkyl;
• each R2 is independently selected from the groups consisting of halogen, cyano, nitro, C1-6-alk(en/yn)yl, C1-6-alk(en/yn)yloxy, C1-6-alk(en/yn)ylsulfanyl, hydroxy, hydroxy-C1-6-alk(en/yn)yl, halo-C1-6-alk(en/yn)yl, halo-C1-6-alk(en/yn)yloxy, C3-8-cycloalk(en)yl, C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, acyl, C1-6-alk(en/yn)yloxycarbonyl, C1-6-alk(en/yn)ylsulfonyl or —NR9R10 wherein R9 and R10 independently represent hydrogen, C1-6-alk(en/yn)yl, C3-8-cycloalk(en)yl, C3-8-cycloalk(en)yl-C1-6 alk(en/yn)yl or aryl, or R9 and R10 together with the nitrogen atom to which they are attached form a 3–7-membered ring which optionally contains one further heteroatom selected from the group consisting of nitrogen and oxygen;
• each R3 which is substituted on AR, is independently selected from the group consisting of halogen, cyano, nitro, C1-6-alk(en/yn)yl, C1-6-alk(en/yn)yloxy, C1-6-alk(en/yn)ylsulfanyl, hydroxy, hydroxy-C1-6-alk(en/yn)yl, halo-C1-6-alk(en/yn)yl, halo-C1-6-alk(en/yn)yloxy, C3-8-cycloalk(en)yl, C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, C1-6-alk(en/yn)ylsulfonyl, aryl, aryl-C1-6-alk(en/yn)yloxy, aryl-C1-6-alk(en/yn)yl, C1-6-alk(en/yn)yloxycarbonyl, acyl, —NHCO—C1-6-alk(en/yn)yl, —CONR11R12 wherein R11 and R12 independently represent hydrogen, C1-6-alk(en/yn)yl, C3-8-cycloalk(en)yl, C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl or aryl, or R11 and R12 together with the nitrogen to which they are attached form a 3–7-membered ring which optionally contains one further heteroatom selected from the group consisting of nitrogen and oxygen;
• or NR13R14 wherein R13 and R14 independently represent hydrogen, C1-6-alk(en/yn)yl, C3-8-cycloalk(en)yl, C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl or aryl;
• or R13 and R14 together with the nitrogen to which they are attached form a 3–7-membered ring which optionally contains one further heteroatom selected from the group consisting of nitrogen and oxygen;
• or an acid addition salt thereof.