Agents for treating human illnesses based on β-catenin, and the production and use thereof

A peptide or polypeptide obtained from the armadillo domain of human β-catenin polypeptide which inhibits the interaction of human β-catenin polypeptide and a transcription factor or tumor suppressor protein, wherein said peptide or polypeptide is selected from the group consisting of peptides or polypeptides consisting of the sequences shown in SEQ ID NO:

• 6 having a mutation in Phe in position 30, a mutation in His in position 37 or both;
• SEQ ID NO:
• 7 having a mutation in Arg in position 9, a mutation in Lys in position 27 or both;
• SEQ ID NO:
• 8 having a mutation in Trp in position 32, a mutation in Arg in position 36, a mutation in Lys in position 39 or any combination of mutations thereof;
• SEQ ID NO:
• 9 having a mutation in Lys in position 5, a mutation in Trp in position 34, a mutation in Arg in position 37 or any combination of mutations thereof;
• SEQ ID NO:
• 10 having a mutation in Lys in position 4;
• and SEQ ID NO:
• 11 having a mutation in Lys in position 6, a mutation in Arg in position 28, a mutation in Arg in position 40, a mutation in His in position 41 or any combination of mutations thereof, wherein said mutation replaces the indicated amino acid with an aliphatic amino acid.