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US 7,067,315 B2Granted
Identification of anti-protozoal agents
AssigneesPresident and Fellows of Harvard College, University of Vermont
InventorsNicholas J. Westwood, Gary E. Ward, Kimberly L. Carey, Timothy J. Mitchinson
Life of this patent
Estimating the term…
Abstract
The present invention provides novel assay systems and methods for monitoring cell invasion by protozoal parasites. The present invention further provides methods of using these assays systems to identify compounds that treat or prevent protozoal infection. The present invention further provides pharmaceutical compositions that have anit-protozoal activity and methods of treating infections.
Claims11
A method for preventing an Apicomplexan parasitic infection, comprising:
- administering to a cell in need of such treatment, an effective amount of an Apicomplexan parasite inhibitor to prevent Apicomplexan parasitic infection in the cell, wherein the Apicomplexan parasite inhibitor is selected from the group consisting of molecules numbered 108296, 244378, 143088, 143267, 144939, 157591, 157808, 156079, 267405, 118793, 137846, 137861, 144146, 115556, 256729, 108343, 156579, 158513, 141852, 235236, 152813, 102260 as depicted in FIGS. 6A–6G and listed in Table 1.
Dependencies are inferred from the claim text.