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US 7,067,307 B2Granted
Bioartificial device for the storage, cultivation and/or multiplication of cells
AssigneeRaimung Margreiter
InventorsBoris-Wolfgang Hochleitner, Paul Hengster
Life of this patent
Estimating the term…
Abstract
The bioartificial reactor has a reactor vessel. A cell culture chamber in the reactor, in particular for liver cells, is divided off from a flow chamber for a nutritive medium and from a flow chamber for plasma and blood by semipermeable walls. At least one flow chamber is formed as a tube that is helically wound in the shape of a screw and that is made of semipermeable material.
Claims50
A bioartificial device, comprising:
- a reactor vessel having a first end and a second opposite end, said reactor vessel being formed with a cell culture chamber, a first throughflow chamber for a nutrient medium separated from said cell culture chamber by a semipermeable wall and including an inlet end adjacent said first end of said reactor vessel and an outlet end adjacent said second end of said reactor vessel, and a second throughflow chamber for a body substance separated from said cell culture chamber by a semipermeable wall and including an inlet end adjacent said first end of said reactor vessel and an outlet end adjacent said second end of said reactor vessel, said first throughflow chamber for the nutrient medium being centrally disposed and being cylindrical with a wall including a semi-permeable membrane, and said second throughflow chamber being formed by a tube of semi-permeable material helically disposed in said cell culture chamber;
- said inlet ends of said first and second throughflow chambers being in fluid communication with feed connections disposed on said first end of said reactor vessel and said outlet ends of said first and second throughflow chambers being in fluid communication with discharge connections disposed on said first end of said reactor vessel with tubes guided through said reactor vessel and extending from said discharge connections to said outlet ends of said throughflow chambers.
A bioartificial device, comprising:
- a reactor vessel having a first end and a second opposite end, said reactor vessel being formed with a cell culture chamber, a first throughflow chamber for a nutrient medium separated from said cell culture chamber by a semipermeable wall and including an inlet end adjacent said first end of said reactor vessel and an outlet end adjacent said second end of said reactor vessel, and a second throughflow chamber for a body substance separated from said cell culture chamber by a semipermeable wall and including an inlet end adjacent said first end of said reactor vessel and an outlet end adjacent said second end of said reactor vessel, at least one of said first and second throughflow chambers being formed by a tube of semi-permeable material helically disposed in said cell culture chamber and at least one of said first and second throughflow chambers being supported on a driven carrier;
- said inlet ends of said first and second throughflow chambers being in fluid communication with feed connections disposed on said first end of said reactor vessel and said outlet ends of said first and second throughflow chambers being in fluid communication with discharge connections disposed on said first end of said reactor vessel with tubes guided through said reactor vessel and extending from said discharge connections to said outlet ends of said throughflow chambers.
A bioartificial device, comprising:
- a reactor vessel having a first end and a second opposite end, said reactor vessel being formed with a cell culture chamber, a first throughflow chamber for a nutrient medium separated from said cell culture chamber by a semipermeable wall and including an inlet end adjacent said first end of said reactor vessel and an outlet end adjacent said second end of said reactor vessel, and a second throughflow chamber for a body substance separated from said cell culture chamber by a semipermeable wall and including an inlet end adjacent said first end of said reactor vessel and an outlet end adjacent said second end of said reactor vessel at least one of said first and second throughflow chambers being formed by a tube of semi-permeable material helically disposed in said cell culture chamber, said reactor vessel being formed with a driven peripheral wall, and each said throughflow chamber being disposed on a stationary support;
- said inlet ends of said first and second throughflow chambers being in fluid communication with feed connections disposed on said first end of said reactor vessel and said outlet ends of said first and second throughflow chambers being in fluid communication with discharge connections disposed on said first end of said reactor vessel with tubes guided through said reactor vessel and extending from said discharge connections to said outlet ends of said throughflow chambers.
A bioartificial device, comprising:
- a reactor vessel having a first end and a second opposite end, said reactor vessel being formed with a cell culture chamber, a first throughflow chamber for a nutrient medium separated from said cell culture chamber by a semipermeable wall and including an inlet end adjacent said first end of said reactor vessel and an outlet end adjacent said second end of said reactor vessel, and a second throughflow chamber for a body substance separated from said cell culture chamber by a semipermeable wall and including an inlet end adjacent said first end of said reactor vessel and an outlet end adjacent said second end of said reactor vessel, at least one of said first and second throughflow chambers being formed by a tube of semi-permeable material helically disposed in said cell culture chamber, said inlet ends of said first and second throughflow chambers being in fluid communication with feed connections disposed on said first end of said reactor vessel and said outlet ends of said first and second throughflow chambers being in fluid communication with discharge connections disposed on said first end of said reactor vessel with tubes guided through said reactor vessel and extending from said discharge connections to said outlet ends of said throughflow chambers.
Dependencies are inferred from the claim text.