Device containing cytophilic islands that adhere cells separated by cytophobic regions
AssigneePresident and Fellows of Harvard College
InventorsRahul Singhvi, Amit Kumar, George M. Whitesides, Donald E. Ingber, Gabriel P. Lopez, Daniel I. C. Wang, Gregory N. Stephanopoulos
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Abstract
The invention provides a device for adhering cells in a specific and predetermined position, and associated methods. The device includes a plate defining a surface and a plurality of cytophilic islands that adhere cells, isolated by cytophobic regions to which cells do not adhere, contiguous with the cytophilic islands. The islands or the regions or both may be formed of a self-assembled monolayer (SAM).
Claims19
A device for adhering at least one cell in a specific and predetermined pattern comprising:
- a surface;
- and
- a plurality of islands in a specific and predetermined pattern over the surface that adhere cells to the islands, the islands isolated from each other by a region contiguous with the islands and to which the cells do not adhere, and wherein the islands or the region in which the cells do not adhere or both comprise a self-assembled monolayer.
Dependencies are inferred from the claim text.