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US 7,067,291 B2Granted
Biocatalytic preparation of enantiomerically enriched aminopentanenitrile
AssigneePfizer Inc.
InventorsDavid R. Allen, Vadim V. Mozhaev, Rao H. Valivety
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Abstract
Methods for preparing enantiomerically enriched aminopentanenitriles are provided. The methods involve selective acylation of an enantiomeric mixture of 3-aminopentanenitrile or selective hydrolysis of an enantiomeric mixture of 3-aminopentanenitrile amide in the presence of an enzyme selected from the group comprising lipase, esterase, and acylase. The methods yield R-aminopentanenitrile, which can be used to produce pharmaceutical products.
Claims4
A method for preparing enantiomerically enriched 3-aminopentanenitriles comprising the steps of:
- providing an enantiomeric mixture containing R-3-aminopentanenitrile R-APN) and S-3-aminopentanenitrile (S-APN):
- and
- reacting the enantiomeric mixture with an acyl donor in the presence of an enzyme to selectively acylate one of R-APN and S-APN;
- wherein the enzyme includes penicillin acylase.
1 more element
Dependencies are inferred from the claim text.