Method for production of polyketides
AssigneeKosan Biosciences, Inc.
InventorsRika Regentin, Ruchir P. Desai
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Abstract
A method for the production of a polyketide by fermentation comprising the steps of growing a culture of a polyketide-producing organism at a pH value conducive to cell growth for a time sufficient to generate the producing culture, lowering the pH of the culture to a value conducive to polyketide product stability, continuing the fermentation until a maximal titer of polyketide is achieved, and optionally extracting the polyketide from the culture.
Claims17
A method for the production of a polyketide by fermentation, comprising the steps of growing a culture of a polyketide-producing organism at a pH value conducive to cell growth for a time sufficient to generate the producing culture between about pH 6 and about pH 7, lowering the pH of the culture to a value conducive to polyketide product stability between about pH 5 and about pH 6, continuing the fermentation until a maximal titer of polyketide is achieved, and optionally extracting the polyketide from the culture.
Dependencies are inferred from the claim text.