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AssigneeAbbott Laboratories
InventorsPradip Mukerji, Yung-Sheng Huang, Tapas Das, Jennifer Thurmond, Amanda Eun-Yeong Leonard, Suzette L. Pereira
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The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 5 (i.e., “Δ5-desaturase”) and at carbon 6 (i.e., “Δ6-desaturase”) and to uses thereof. In particular, Δ5-desaturase may be utilized, for example, in the conversion of dihomo-γ-linolenic acid (DGLA) to arachidonic acid (AA) and in the conversion of 20:4n-3 to eicosapentaenoic acid (EPA). Delta-6 desaturase may be used, for example, in the conversion of linoleic (LA) to γ-linolenic acid (GLA). AA or polyunsaturated fatty acids produced therefrom may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.
An isolated nucleic acid sequence encoding a polypeptide having at least 70% sequence identity to SEQ ID NO:14, wherein said nucleic acid sequence encodes a functionally active Δ6-desaturase.
A method of producing a desaturase in a host cell in vitro comprising the steps of:
A vector comprising:
A method for producing a polyunsaturated fatty acid comprising the steps of:
An isolated nucleic acid sequence encoding a polypeptide wherein said polypeptide:
Dependencies are inferred from the claim text.