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US 7,067,274 B2Granted
Compositions and methods for the screening pro-apoptotic compounds
AssigneesGenentech, Inc., The Burnham Institute
InventorsWayne J. Fairbrother, Matthew C. Franklin, Heidi Jenii Ackerly Wallweber, Linda Orren Elliott, Saloumeh Kadkhodayan, Domagoj Vucic, Guy Salvesen
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Abstract
The present invention is directed to compositions of matter useful for the enhancement of apoptosis in mammals and to methods of using those compositions of matter for the same.
Claims4
A method of screening for a compound that inhibits caspase interaction with a melanoma-inhibitor of apoptosis (ML-IAP) chimera comprising:
- a. contacting a caspase polypeptide and an IAP polypeptide in the presence of said compound, wherein said IAP polypeptide is SEQ ID No:
- 2;
- b. detecting the amount of caspase activity when compared to the amount of caspase activity without the presence of the modulating compound.
Dependencies are inferred from the claim text.