Methods and compositions for treatment of central nervous system disorders
AssigneesTargacept, Inc., Medical College of Georgia Research Institute, Inc.
InventorsMerouane Bencherif, Mario B. Marrero
Life of this patent
Estimating the term…
Abstract
The invention provides methods of screening for substances having an effect on a nicotine receptor by contacting a cell having a nicotine receptor with a test substance; and determining any increase or decrease in phosphorylation of Janus-Activated Kinase 2 (JAK2). An increase in phosphorylation of JAK2 indicates that the test substance stimulates the nicotine receptor, and wherein a decrease in phosphorylation of JAK2 indicates that the test substance inhibits the nicotine receptor. The invention also provides screening methods for identification of substances that affect nicotine receptor activity through activity mediated by the AT2 receptor. Related pharmaceutical compositions and methods of treatment are also provided.
Claims11
A composition, comprising,
- a) a substance that binds α7 nicotinic acetylcholine receptors (α7-nAChR);
- and
- b) at least one angiotensin-converting enzyme (ACE) inhibitor;
- and
- c) a pharmaceutically acceptable carrier.
A composition for reducing apoptosis mediated by a β-amyloid polypeptide in mammalian neurons, comprising,
- a) a substance that binds α7-nAChR;
- and
- b) at least one ACE inhibitor;
- and
- c) a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.