Back to results
US 7,067,259 B2Granted
Multidrug resistance proteins in Drosophila and Anopheles
AssigneeInstitut Pasteur
InventorsCharles W. Roth, Paul T. Brey, Inge Holm, Marine Grailles, Andrey Rzhetsky
Life of this patent
Estimating the term…
Abstract
The invention provides, inter alia, isolated nucleic acid molecules that comprise nucleic acids encoding multiple drug resistance proteins from Drosophila melanogaster or Anopheles gambiae, herein referred to as dMRP or gMRP, respectively, vectors encoding dMRP or gMRP, and host cells transformed with vectors containing these nucleic acids.
Claims8
A purified polynucleotide comprising a nucleotide sequence encoding SEQ ID NO:
- 1, or a fragment of SEQ ID NO:
- 1 comprising at least an ATP binding domain.
A purified polynucleotide that hybridizes to either strand of a denatured, double-stranded DNA encodinci SEQ ID NO:
- 1 under conditions of high stringency, wherein said conditions comprise hybridization at 65° C. in 1% BSA, 0.25 M NaH2PO4 pH 7.2, 1 mM EDTA, and 150 μg/ml salmon sperm DNA, and further comprise washing at 65° C. in 40 mM NaH2PO4, pH 7.2, 1% SDS, and 1 mM EDTA.
Dependencies are inferred from the claim text.