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US 7,067,248 B2Granted
Screening method for orthopoxvirus antivirals
AssigneeSiga Technologies, Inc.
InventorsDennis E. Hruby, Tove C. Bolken, Chelsea Byrd
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Abstract
The focus of the present invention is an effective anti-poxvirus drug for use in treating or preventing human disease caused by pathogenic poxviruses. More particularly, the present invention relates to antiviral drugs that target the poxvirus proteinase responsible for core protein maturation, a step which is absolutely essential for the production and spread of infectious virions.
Claims13
An assay comprising the steps of:
- infecting cultured cells with vaccinia virus;
- co-transfecting the cells with one or more plasmids comprising DNA encoding the I7L protease enzyme and at least one substrate, such that both the substrate protein and enzyme are constitutively expressed;
- and
- measuring the amount of cleavage product of the I7L protease.
1 more element
Dependencies are inferred from the claim text.