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US 7,067,245 B2Granted
Selection methods
OwnerJacob Nathaniel Wohlstadterinventor
Life of this patent
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Abstract
A rational method for obtaining a novel molecule capable of a desired interaction with a substrate of interest comprising selecting hosts or replicators which encode said novel molecules based upon cell or replicator growth caused by the desired interaction of the novel molecule and a selection molecule expressed by said host.
Claims8
A method for selecting a virus expressing a molecule having an activity of interest comprising:
- a) growing a population of viruses in a high selection pressure strain of bacteria where said activity of interest confers a growth advantage;
- b) expanding the virus population produced in step (a) by growing said population in a low selection pressure strain of bacteria;
- c) cycling the virus population produced in step (b) through steps (a) and (b) one or more times.
Dependencies are inferred from the claim text.