Fast disintegrating tablet

Improved multiparticulate tablet which disintegrates in contact with the saliva in the mouth in less than 40 seconds, comprising particles of coated active substance and a mixture of excipients being free of effervescent agents, the ratio of excipient mixture to coated active substance particles being 0.4 to 6 parts by weight, the mixture of excipients comprising 1 to 15% by weight based on the weight of the tablet of a disintegration agent selected from the group consisting of croscarmellose, crospovidone and mixtures thereof;

• 30 to 90% by weight, based on the weight of the tablet of a at least two soluble diluent agents with binding properties which consists of a polyol selected from the group consisting of mannitol, xylitol, sorbitol and maltitol and at least one diluent agent being in the form of the directly compressible product with an average particle diameter of 100 to 500 μm, and at least diluent agent being in the form of a powder with an average particle diameter of less than 100 μm, the ratio of directly compressible polyol to powder polyol being 99/1 to 20/80;
• 0.05 to 2% by weight based on the weight of the tablet of a lubricant selected from the group consisting of magnesium stearate, sodium stearyl fumarate, steriac acid, micronized polyoxyethylene glycol and mixtures thereof;
• at least one from the group consisting of sweeteners, flavorings, colors and mixtures thereof;
• and 0.1 to 10% by weight based on the weight of the tablet of a permeabilizing agent selected from the group consisting of precipitated silicas with a high affinity for aqueous solvents, maltodextrins, β-cyclodextrines and mixtures thereof.